Retinal thickening in HLA-B27-associated acute anterior uveitis: evolution with time and association with severity of inflammatory activity.

TitreRetinal thickening in HLA-B27-associated acute anterior uveitis: evolution with time and association with severity of inflammatory activity.
Publication TypeJournal Article
Year of Publication2012
AuthorsBalaskas, K, Ballabeni, P, Guex-Crosier, Y
JournalInvest Ophthalmol Vis Sci
Volume53
Issue10
Pagination6171-7
Date Published2012
DOI10.1167/iovs.12-10026
ISSN1552-5783
Mots-clésAdolescent, Adrenal Cortex Hormones, Adult, Aged, Aged, 80 and over, Female, HLA-B27 Antigen, Humans, Male, Middle Aged, Outcome Assessment (Health Care), Photometry, Prospective Studies, Time Factors, Tomography, Optical Coherence, Uveitis, Anterior, Young Adult
Abstract

PURPOSE: To describe the evolution of retinal thickness in eyes affected with acute anterior uveitis (AAU) in the course of follow-up and to assess its correlation with severity of inflammatory activity in the anterior chamber.

METHODS: 72 eyes (affected and fellow eyes) of 36 patients presenting with HLA-B27-related acute anterior uveitis were included in a prospective, institutional, cohort study. Patients were followed daily until beginning of resolution of inflammatory activity and weekly thereafter. Optical coherence tomography and laser flare photometry were performed at each visit. Treatment consisted of topical corticosteroids. Main outcome measures were retinal thickness of affected eyes, difference in retinal thickness between affected and fellow eyes and their evolution in time, association between maximal retinal thickness, and initial laser flare photometry.

RESULTS: Difference in retinal thickness between affected and fellow eyes became significant on average 7 days from baseline and remained so throughout follow-up (P

CONCLUSIONS: Retinal thickness in eyes affected with AAU presents a steep increase over 3 to 4 weeks and then gradually decreases. Severity of inflammation at baseline predicts the amount of retinal thickening in affected eyes. A characteristic pattern of temporal response of retinal anatomy to inflammatory stimuli seems to arise.

Notes

Publication types: JOURNAL ARTICLE

Alternate URL

http://www.ncbi.nlm.nih.gov/pubmed/22879410?dopt=Abstract

Alternate JournalInvest. Ophthalmol. Vis. Sci.
Citation Key / SERVAL ID3286
PubMed ID22879410

                         

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