High constant incidence of second primary colorectal cancer.

TitreHigh constant incidence of second primary colorectal cancer.
Publication TypeJournal Article
Year of Publication2013
AuthorsLevi, F, Randimbison, L, Blanc-Moya, R, Maspoli-Conconi, M, Rosato, V, Bosetti, C, La Vecchia, C
JournalInt J Cancer
Date Published2013 Apr 1
Mots-clésAdult, Aged, Aged, 80 and over, Colorectal Neoplasms, Female, Humans, Incidence, Male, Middle Aged, Neoplasms, Second Primary, Prognosis, Registries, Switzerland

Patients who had a colorectal cancer have a 1.5- to 2-fold excess risk of a second colorectal cancer as compared to the general population, the excess being higher at younger age at diagnosis. To further investigate the risk and the age-relation of the incidence of second primary colorectal cancer, we considered 9,389 first colon and rectal cancers registered in the Vaud Cancer Registry, Switzerland, between 1974 and 2008, and followed-up to the end of 2008 for a total of 44,113 person-years. There were 136 second colorectal cancers versus 90.5 expected, corresponding to a standardized incidence ratio (SIR) of 1.5 (95% confidence interval, CI, 1.3-1.8). The SIRs were not heterogeneous between men and women, and in strata of calendar year at diagnosis, duration of follow-up, and subsite. However, the SIR was 7.5 (95% CI 4.2-12.4) for subjects diagnosed below age 50 and declined thereafter to reach 1.0 (95% CI 0.6-1.6) at age 80 or over. Consequently, the incidence of second primary colorectal cancer was stable, and exceedingly high, around 300-400/100,000 between age 30-39 and 70 or over. This age pattern is consistent with the existence of a single mutational event in a population of highly susceptible individuals.

Alternate URL


Alternate JournalInt. J. Cancer
Citation Key / SERVAL ID3292
PubMed ID22903312

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