Incidence of second sarcomas: a cancer registry-based study.

TitreIncidence of second sarcomas: a cancer registry-based study.
Publication TypeJournal Article
Year of Publication2014
AuthorsLevi, F, Randimbison, L, Maspoli-Conconi, M, Blanc-Moya, R, La Vecchia, C
JournalCancer Causes Control
Volume25
Issue4
Pagination473-477
Date Published04/2014
DOI10.1007/s10552-014-0349-7
ISSN0957-5243 (linking)
ISBN Number1573-7225 (Electronic)
Abstract

BACKGROUND: In high-quality cancer registration systems, about one in eight incident cancers are second primary cancers. This is due to a combination of careful diagnostic ascertainment, shared genetic determinants, shared exposure to environmental factors and consequences of treatment for first cancer.

METHODS: We used data derived from the Swiss population-based cancer Registries of Vaud and Neuchâtel, including 885,000 inhabitants.

RESULTS: Among 107,238 (52% males) first cancers occurring between 1976 and 2010, a total of 126 second sarcomas were observed through active and passive follow-up versus 68.2 expected, corresponding to a standardized incidence ratio (SIR) of 1.85 (95 % CI 1.5-2.2). Significant excess sarcoma risks were observed after skin melanoma (SIR = 3.0), breast cancer (2.2), corpus uteri (2.7), testicular (7.5), thyroid cancer (4.2), Hodgkin lymphoma (5.7) and leukemias (4.0). For breast cancer, the SIR was 3.4 ≥ 5 years after sarcoma diagnosis.

CONCLUSIONS: The common denominator of these neoplasms is the utilization of radiotherapy in their management. Some sarcomas following breast cancer may be due to shared genetic components (i.e., in the Li-Fraumeni syndrome), as well as possibly to shared environmental factors, with sarcomas, including overweight, selected dietary and reproductive factors which are, however, too little defined for any quantitative risk assessment.

Notes

Publication types: Journal Article Publication Status: ppublish

Alternate URL

http://www.ncbi.nlm.nih.gov/pubmed/24463790?dopt=Abstract

First publication date (online)

01/2014

WOS ID (UT)

000332647500007

Alternate JournalCancer Causes Control
Citation Key / SERVAL ID3529
Peer reviewRefereed
PubMed ID24463790
Thème IUMSP et mots clés: 
                         

IUMSP | www.iumsp.ch
Institut universitaire de médecine sociale et préventive
Route de la Corniche 10, 1010 Lausanne - Switzerland
+41 21 314 72 72 | iumsp@chuv.ch

Go to top